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主要研究成果:
发表文章
- Xue, Y., Liu, J.Q., Zheng, K.W., Kan, Z.Y., Hao, Y.H. and Tan, Z. (2011) Kinetic and Thermodynamic Control of G-Quadruplex Folding. Angew. Chem. Int. Ed., 50, 8046-8050.
- Wang, Q., Liu, J.Q., Chen, Z., Zheng, K.W., Chen, C.Y., Hao, Y.H. and Tan, Z. (2011) G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase. Nucleic Acids Res., 39, 6229-6237.
- Chen, C.Y., Wang, Q., Liu, J.Q., Hao, Y.H. and Tan, Z. (2011) Contribution of Telomere G-Quadruplex Stabilization to the Inhibition of Telomerase-Mediated Telomere Extension by Chemical Ligands. J. Am. Chem. Soc., 133, 15036-15044.
- Zheng, K.W., Zhang, D., Zhang, L.X., Hao, Y.H., Zhou, X. and Tan, Z. (2011) Dissecting the strand folding orientation and formation of g-quadruplexes in single- and double-stranded nucleic acids by ligand-induced photocleavage footprinting. J. Am. Chem. Soc., 133, 1475-1483.
- Wang, Q., Ma, L., Hao, Y.H. and Tan, Z. (2010) Folding equilibrium constants of telomere g-quadruplexes in free state or associated with proteins determined by isothermal differential hybridization. Anal. Chem., 82, 9469-9475.
- Liu, J.Q., C.Y. Chen, Y. Xue, Y.H. Hao, & Z. Tan, (2010) G-Quadruplex Hinders Translocation of BLM Helicase on DNA: A Real-Time Fluorescence Spectroscopic Unwinding Study and Comparison with Duplex Substrates. J Am Chem Soc, 132(30): 10521-7.
- Zheng, K.W., Z. Chen, Y.H. Hao, & Z. Tan, (2010) Molecular crowding creates an essential environment for the formation of stable G-quadruplexes in long double-stranded DNA. Nucleic Acids Res, 38(1): 327-38.
- Chen, Z., Zheng, K. W., Hao, Y. H. and Tan, Z. (2009) Reduced or Diminished Stabilization of the Telomere G-Quadruplex and Inhibition of Telomerase by Small Chemical Ligands under Molecular Crowding Condition. J Am Chem Soc 131(30): 10430-38.
- Tang, J., Kan, Z. Y., Yao, Y., Wang, Q., Hao, Y. H. and Tan, Z. (2008) G-quadruplex preferentially forms at the very 3' end of vertebrate telomeric DNA. Nucleic Acids Res 36(4): 1200-8.
- Yuan, B. F., Zhuang, X. Y., Hao, Y. H. and Tan, Z. (2008) Kinetics of base stacking-aided DNA hybridization. Chem Commun (Camb)(48): 6600-2.
- Wang, F., Zhao, Y., Hao, Y. and Tan, Z. (2008) Identification of low-abundance alternatively spliced mRNA variants by exon exclusive reverse transcriptase polymerase chain reaction. Anal Biochem 383: 307-10.
- Xue, Y., Kan, Z. Y., Wang, Q., Yao, Y., Liu, J., Hao, Y. H. and Tan, Z. (2007) Human telomeric DNA forms parallel-stranded intramolecular G-quadruplex in K+ solution under molecular crowding condition. J Am Chem Soc 129(36): 11185-91.
- Yao, Y., Wang, Q., Hao, Y. H. and Tan, Z. (2007) An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules. Nucleic Acids Res 35(9): e68.
- Kan, Z. Y., Lin, Y., Wang, F., Zhuang, X. Y., Zhao, Y., Pang, D. W., Hao, Y. H. and Tan, Z. (2007) G-quadruplex formation in human telomeric (TTAGGG)4 sequence with complementary strand in close vicinity under molecularly crowded condition. Nucleic Acids Res 35(11): 3646-53.
- Zhuang, X. Y., Tang, J., Hao, Y. H. and Tan, Z. (2007) Fast detection of quadruplex structure in DNA by the intrinsic fluorescence of a single-stranded DNA binding protein. J Mol Recognit 20(5): 386-91.
- Yuan, B. F., Xue, Y., Luo, M., Hao, Y. H. and Tan, Z. (2007) Two DNAzymes targeting the telomerase mRNA with large difference in Mg2+ concentration for maximal catalytic activity. Int J Biochem Cell Biol 39(6): 1119-29.
- Kan, Z. Y., Yao, Y., Wang, P., Li, X. H., Hao, Y. H. and Tan, Z. (2006) Molecular crowding induces telomere G-quadruplex formation under salt-deficient conditions and enhances its competition with duplex formation. Angew Chem Int Ed Engl 45(10): 1629-32.
- Zhao, Y., Zeng, Z. X., Kan, Z. Y., Hao, Y. H. and Tan, Z. (2005) The folding and unfolding kinetics of the i-motif structure formed by the C-rich strand of human telomere DNA. Chembiochem 6(11): 1957-60.
- Zeng, Z. X., Zhao, Y., Hao, Y. H. and Tan, Z. (2005) Tetraplex formation of surface-immobilized human telomere sequence probed by surface plasmon resonance using single-stranded DNA binding protein. J Mol Recognit 18(3): 267-71.
- Shao, L., Li, Q. H., Wang, J. and Tan, Z. (2005) Fragmentation and rapid shortening of telomere in HeLa cells in the early phase of hydroxyl radical-induced apoptosis. Cancer Biol Ther 4(3): 336-41.
- Li, W. G., Li, Q. H. and Tan, Z. (2005) Epigallocatechin gallate induces telomere fragmentation in HeLa and 293 but not in MRC-5 cells. Life Sci 76(15): 1735-46.
- Li, W. G., Li, Q. H. and Tan, Z. (2005) Detection of telomere damage as a result of strand breaks in telomeric and subtelomeric DNA. Electrophoresis 26(3): 533-6.
- Zhao, Y., Kan, Z. Y., Zeng, Z. X., Hao, Y. H., Chen, H. and Tan, Z. (2004) Determining the folding and unfolding rate constants of nucleic acids by biosensor. Application to telomere G-quadruplex. J Am Chem Soc 126(41): 13255-64.
- Yuan, B. F., Hao, Y. H. and Tan, Z. (2004) Universal sensing strategy for the detection of nucleic acid targets by optical biosensor based on surface plasmon resonance. Clin Chem 50(6): 1057-60.
- Shao, L., Li, Q. H. and Tan, Z. (2004) L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun 324(2): 931-6.
- Hao, Y. H. and Tan, Z. (2002) The generation of long telomere overhangs in human cells: a model and its implication. Bioinformatics 18(5): 666-71.
- Tan, Z. (2001) Simulated shortening of proliferation-restricting telomeres during clonal proliferation and senescence of human cells. Exp Gerontol 36(1): 89-97.
- Hao, Y. H. and Tan, Z. (2001) Telomeres at the chromosome X(p) might be critical in limiting the proliferative potential of human cells. Exp Gerontol 36(10): 1639-47.
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